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Pure Greens Lab CBD Oil You can pair hemp oil with soothing ingredients to help heal better such as essential oils, Aloe Vera and coconut oil to purify and boost the skin. No reports have surfaced regarding the side effects of using the oil, but some people have reported a change in weight and appetite, mild fatigue and diarrhoea during its use. When considering the application of hemp oil, it is generally considered to be safe when topically applied directly on the skin.